Coronavirus pleomorphism
نویسندگان
چکیده
The coronavirus is always idealized as a spherical capsid with radially protruding spikes. However, histologically, in the tissues of infected patients, capsids cross section are elliptical, and only sometimes [Neuman et al., “Supramolecular architecture severe acute respiratory syndrome revealed by electron cryomicroscopy,” J Virol, 80, 7918 (2006)]. This ellipticity implies that coronaviruses oblate or prolate both. We call this diversity shapes, pleomorphism. Recently, rotational diffusivity suspension was calculated, from first principles, using general rigid bead-rod theory [Kanso “Coronavirus diffusivity,” Phys Fluids 32, 113101 (2020)]. did so beading then also replacing each its bulbous spikes single bead. In paper, we use energy minimization for spreading spikes, charged identically, over capsids. to explore role such cross-sectional on diffusivity, transport property around which cell attachment revolves. learn drastically decreases be it prolate.
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ژورنال
عنوان ژورنال: Physics of Fluids
سال: 2022
ISSN: ['1527-2435', '1089-7666', '1070-6631']
DOI: https://doi.org/10.1063/5.0094771